Higher Risk Remains 25 Years After Treatment of Cervical Neoplasia

Higher Risk Remains 25 Years After Treatment of Cervical Neoplasia

Women treated for grade 3 cervical intraepithelial neoplasia (CIN3) are at increased risk for cervical or vaginal cancers up to 25 years later, reports a study published online in BMJ.

Researchers collected data from Swedish national registries on women who had been diagnosed with and treated for CIN3 between 1958 and 2000. Compared with other Swedish women, those with earlier CIN3 diagnoses had an incidence ratio for invasive cervical cancer of 2.3, and the more recent the diagnosis, the higher the risk (those treated in 1991-2000 had almost twice the risk as those treated in 1958-1970). In addition, the risk increase was accelerated among women aged 50 or older at CIN3 diagnosis.

Risks for vaginal cancer were also elevated, but did not show the worsening historical trend that cervical cancers did.

The authors say patients treated for CIN3 should be offered cytologic screening “at regular intervals, preferably for at least 25 years.”

BMJ article (Free abstract; full text requires subscription)

BMJ editorial (Subscription required)

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