Therapeutics Letter 77: March – April 2010
Why is a new systematic review necessary?
However, getting accurate data entered and analysed is insufficient on its own. Cochrane reviews require assessing the risk of bias for each included RCT using the Risk of Bias Tool. Using this tool we found some risk of bias for each of the 12 included RCTs. Table 2.
How can CHD SAEs decrease, but not total SAEs?
- Systematic reviews and meta-analyses are challenging and require much more than locating RCTs and plugging in the numbers.
- The claimed mortality benefit of statins for primary prevention is more likely a measure of bias than a real effect.
- The reduction in major CHD serious adverse events with statins as compared to placebo is not reflected in a reduction in total serious adverse events.
- Statins do not have a proven net health benefit in primary prevention populations and thus when used in that setting do not represent good use of scarce health care resources.
|The draft of this Therapeutics Letter was submitted for review to 45 experts and primary care physicians in order to correct any inaccuracies and to ensure that the information is concise and relevant to clinicians.|
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