A new report funded by AHRQ has found that serious adverse events resulting from vaccines routinely used in the United States are rare. The report, highlighted in the July issue of Pediatrics, provides the most comprehensive review to date of published studies on the safety of routine vaccines recommended for children in the United States. The report, “Safety of Vaccines Used for Routine Immunization in the United States,” found scientific evidence that addresses several common concerns about a variety of vaccines. For example, the report found strong scientific evidence that there is no link between:
- Measles, mumps and rubella (MMR) vaccines and autism
- Pneumonia and influenza vaccines and cardiovascular or cerebrovascular events in the elderly
- MMR, diphtheria, tetanus and pertussis; tetanus and diphtheria; Haemophilus influenza type b; and hepatitis B vaccines and childhood leukemia
In addition, the report found moderately strong scientific evidence that there is not a link between human papillomavirus (HPV) vaccines and appendicitis, stroke, seizures, venous thromboembolism, onset of juvenile arthritis or onset of type 1 diabetes. It also found that there is not a link between inactivated influenza vaccines and adverse pregnancy outcomes (such as miscarriage, low birth weight and premature birth) for women who receive the vaccine while pregnant. The AHRQ evidence review, announced July 1, was conducted by the Southern California Evidence-based Practice Center based at the RAND Corporation.